In the Minnesota region during the eighteenth to mid-nineteenth centuries, métis, or mixed-ancestry, people often acted as bridges between white and Native American communities. The Métis cultural community of Pembina formed out of fur trade dynamics and influenced Minnesota during its territorial birth.

Ojibwe oral tradition identifies Little Round Hill, a small elevation on the banks of the Crow Wing River, as the location of a late-1700s French fur trading fort and a skirmish between Ojibwe hunter-traders and Dakota warriors. Located in Old Wadena County Park at the confluence of the Partridge and Crow Wing Rivers, it was the site of the first intensive archaeological excavation within Wadena County.

Gabriel Renville was a fur trader, a farmer, and the leader of the Sisseton-Wahpeton Dakota from 1867 until 1892. Related by blood to multiple Dakota bands and mixed-ancestry families, he opposed Ta Oyate Duta (His Red Nation, also known as Little Crow) and other Dakota who fought against settler-colonists in the U.S.–Dakota War of 1862. His choice angered some of his relatives, who saw him as serving the interests of colonists. After the war, he was one of many who worked to reacquire land for the Sisseton-Wahpeton people.