A marked rise in public anti-Semitism in the 1930s spurred a group of Jewish leaders in the Twin Cities and Duluth to form the Anti-Defamation Council of Minnesota in 1938. In the 1950s the focus of the council shifted from defensive actions to teaching campaigns. These efforts aimed to fight ignorance and improve social relations. The renamed Jewish Community Relations Council of Minnesota and the Dakotas continues this mission in the twenty-first century.

In the late nineteenth century, some of the Jewish immigrants who had originally settled in the Twin Ports of Duluth-Superior saw economic opportunity in the nearby Iron Range of northern Minnesota. From the 1890s through the 1920s they founded retail and service businesses in the region's booming mining towns. Though small in numbers and relatively isolated, Iron Range Jews supported a vibrant communal life through the 1980s, when hard times on the Range led to a general depopulation.

In 1851 Bishop Joseph Cretin needed help to preach the Catholic faith to the growing St. Paul community. In July of that year he asked the Sisters of St. Joseph of Carondelet in Missouri to assist him. Mother St. John Fournier and three Catholic sisters traveled to the city in the fall and quickly influenced the health and welfare of the region.

Two of Duluth's oldest Jewish congregations—Temple Emanuel and Tifereth Israel—had little in common after they were founded in the 1890s. While Temple Emanuel was affiliated with Reform Judaism, Tifereth Israel conducted worship services in the Orthodox tradition. Tifereth Israel's 1945 shift to Conservative Judaism, however, coupled with the decline of Duluth's Jewish population, led the two congregations to unite in 1969 as Temple Israel.