When the Fergus Falls State Hospital opened its doors on July 29, 1890, it became the first state institution in northern Minnesota for patients considered insane. The hospital had a sprawling campus and large stately buildings, built according to the influential asylum plan developed by Philadelphia physician Thomas Kirkbride in the 1850s.

The Basilica of Saint Mary was first known as the Pro-Cathedral of Minneapolis. It cost one million dollars to build and held its first Mass in 1914. In 1926, the Catholic Church made it the first basilica in the United States.