Fur trader and translator George Bonga was one of the first Black people born in what later became the state of Minnesota. His mother was Ojibwe, as were both of his wives. Through these relationships, Bonga was part of the mixed racial and cultural groups that connected trading companies and Native Americans. He frequently guided white travelers and traders through the region. Comfortable in many worlds, Bonga often worked as an advocate for the Ojibwe in their dealings with trading companies and the United States government.

Marvel Cooke was a pioneering journalist and political activist who spent her groundbreaking career in a world where she was often the only female African American. Talking about her work environment for the white-owned newspaper the Compass, she told biographer Kay Mills in 1988, ''there were no black workers there and no women."

Fredrick Lamar McGhee (1861–1912) was Minnesota’s first African American lawyer, its most consequential early civil rights leader, the only Minnesota public figure born in slavery, a renowned orator, and a criminal defense lawyer famous for his courtroom victories. His civil rights work had national reverberations. His break with Booker T. Washington and subsequent alliance with W. E. B. DuBois led to the foundation of the Niagara Movement, and then the NAACP.